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. 2021 Oct 18;11:534. doi: 10.1038/s41398-021-01653-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Aβ pathology included the CSF Aβ/t-tau ratio (A1, A2), frontal lobe Aβ SUVR (B1, B2), left mOFC Aβ SUVR (C1, C2), and right POC Aβ SUVR (D1, D2). Blue lines showed the total effect (c) of apathy on 2-year follow-up cognitive functions, blue dotted lines showed the direct effect (c’), and green lines depicted the mediation effect (a*b) of Aβ pathology. Path weights were only shown for significant paths and were expressed as effect and p-value.