Figure 1.

Experimental schematic. C57BL/6 male mice aged at 2.5 months old were received preformed fibril (PFF) or control substances [monomeric alpha-synuclein (αSyn) or phosphate buffered saline (PBS)] into the unilateral dorsal striatum, and behavioral tests were done at baseline and before sacrifice. The mouse brain was isolated at each time point for analysis using immunohistochemistry and a western blot as provided in detail. dpi, day postinjection.