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. 2021 Oct 5;12:701151. doi: 10.3389/fphys.2021.701151

Table 1.

Characteristics of studies included in the present study.

Author, year Participants Mean age Participants (M/F) Intervention Frequency, duration, and intensity of aerobic exercise Outcomes/measure
Cetin et al., 2010 Healthy elderly 70.3 29 (24/5) T: walking
C: no training
50min/day, 3days/week, 6months, and 60–75% HRmax VE/Spectrofluorometrically
TAC/Colorimetric assay kit
Mohammadi et al., 2018 Overweight elderly men 72.4 24 (24/0) T: aerobic exercises
C: maintain their
usual lifestyle
45–60min/day, 3days/week, 8weeks, and 90–95% HRmax NO/Zebra Kit
Hejazi et al., 2019 Elderly healthy women 65.5 21 (0/21) T: aerobic exercises
C: maintain their usual lifestyle
45–60min/day, 4days/week, 8weeks, and 50–70% HRmax 8-OHdG/ELISA
Groussard et al., 2015 Adults with ESKD 67.6 18 (13/5) T: specialized cycle ergometers
C: no training
30min/day, 3days/week, 3months, and 50–60% HRmax Ox-LDL/ELISA
GSH/GSSG/GSH/GSSG-412 kit
SOD/Ransod Kit
GPX/Ransel Kit
Alghadir et al., 2016 Healthy elderly 69.7 100 (70/30) T: treadmill, bicycle, and StairMaster
C: no training
45–60min/day, 3days/week, 24weeks, and 60–70% HRmax TAC/Colorimetric Assay Kit
MDA/HPLC
8-OHdG/ELISA
Fatouros et al., 2004 Elderly healthy man 72.3 19 (19/0) T: walking/jogging
C: no training
60min/day, 3days/week, 16weeks, and 50–80% HRmax MDA/TBA
3-NT/HPLC
TAC/Chemiluminescence
GPX/Hitachi 2001 UV/VIS spectrophotometer
Osali, 2020 Women with metabolic syndrome 62.3 22 (0/22) T: walking/running
C: no training
36–51min/day, 7days/week, 6weeks, and 65–75% HRmax TAC/The ferric reducing ability of plasma
MDA/Esterbauer and Cheeseman method
Xiong and Feng, 2015 Healthy elderly 63.4 40 (20/20) T: walking
C: no training
35–45min/day, 60days SOD, GPX, GSH, MDA
Liu et al., 1996 Elderly healthy man 64.8 86 (86/0) T: Tai Chi
C: no training
60min/day, 5days/week, and 1year SOD/Catechol Autoxidation
LPO/TBA colorimetry
Sha, 2007 Adults with AS 64.1 40 (24/16) T: Tai Chi
C: no training
60–120min/day, 5–7days/week, and 18months NO/NR
Xie and Bai, 2014 Adults with EH 60–70 50 (25/25) T: Tai Chi
C: no training
60min/day, 5days/week, 12weeks, and 40–60% HRmax NO/NR
Shi et al., 1995 Adults with EH 68.2 32 (25/7) T: walking/jogging/Tai Chi
C: no training
60min/day, 3years, and 70% HRmax LPO/TBA
Yao et al., 2001 Adults with hypertension 65.8 41 (10/31) T: aerobic exercises
C: no training
60min/day, 6days/week, 7weeks, and 50–60% HRmax NO/NR
Zhu et al., 2008 Elderly healthy women 63 75 (0/75) T: Wu Qin Xi
C: no training
45min/day, 16weeks, and moderate intensity SOD/XO
MDA/TBA
He et al., 2011 Elderly healthy women 62.8 80 (0/80) T: Baduanjin
C: no training
45min/day, 20weeks, and moderate intensity SOD/XO
MDA/TBA
Zhen et al., 2014 Adults with EH 69.6 55 (29/26) T: conventional treatment and Baduanjin
C: conventional treatment
30min/day, 5days/week, and 12weeks NO/NR
Liu and Jin, 2010 Elderly healthy women 65.7 62 (0/62) T: Yi Jinjing
C: no training
40–50min/day, 6days/week, 6months, and 60–75% HRmax SOD/Hydroxylamine oxidation
GPX/DTNB direct colorimetry
MDA/TBA colorimetry
Wang et al., 2015 Adults with T2DM 64.2 100 (45/55) T: Baduanjin
C: no training
60min/day, 3days/week, and 1year 8-isoPGF2/ELISA
SOD/Fluorescence
Yang et al., 2015 Adults with ISH 68.1 166 (59/107) T: conventional treatment and bicycling
C: conventional treatment
30min/day, 3days/week, 20weeks, and 60–80% HRmax NO/Greiss
Ma et al., 2017 Adults with CHF 61–78 110 (73/37) T: conventional treatment and combination of aerobic activity
C: conventional treatment
30–40min/day, 4days/week, 12weeks, and 60–80% HRmax NO/NR

VE, vitamin E; TAC, total antioxidant capacity; NO, nitric oxide; 8-OHdG, 8-hydroxy-2'-deoxyguanosine; ELISA, enzyme linked immunosorbent assay; ESKD, end-stage kidney disease; Ox-LDL, oxidized low-density lipoprotein; GSH/GSSG, reduced glutathione/oxidized glutathione; SOD, superoxide dismutase; GPX, glutathione peroxidase; MDA, malondialdehyde; HPLC, high performance liquid chromatography; TBA, thiobarbituric acid; 3-NT, 3-Nitrotyrosine; GPX, glutathione peroxidase; GSH, glutathione; LPO, lipid peroxide; AS, atherosclerosis; NR, nitrate reductase; EH, essential hypertension; XO, xanthine oxidase; DTNB, 5,5'-Dithiobis (2-nitrobenzoic acid); T2DM, type 2 diabetes mellitus; 8-isoPGF2, 8-iso-prostaglandin F2α; ISH, isolated systolic hypertension; and CHF, coronary heart disease with chronic heart failure.