Table 2.
The clinical data and laboratory data in different severity obstructive sleep apnea.
| Normal | Mild OSA | Moderate OSA | Severe OSA | P-value | |
|---|---|---|---|---|---|
| N | 18 | 15 | 13 | 29 | |
| Age (years old) | 38.28 ± 8.58 | 39.00 ± 6.70 | 41.62 ± 10.24 | 38.83 ± 8.28 | 0.72 |
| BMI (kg/m2) | 24.89 ± 2.97 | 24.46 ± 2.89 | 26.46 ± 1.84 | 28.01 ± 3.54 | 0.01 |
| Hypertension (n) | 3 | 2 | 3 | 18 | <0.01 |
| Current smoker (n) | 3 | 2 | 2 | 12 | 0.09 |
| AHI (events/h) | 0.85 (0.6, 1.8) | 8.3 (6.6, 11.5) | 19.8 (16.20, 24.75) | 57.7 (46.4, 69.8) | <0.01 |
| AI (events/h) | 5.25 (3.3, 8.2) | 7 (4.7, 9.9) | 7.8 (5.5, 11.45) | 16 (7.4, 27.5) | <0.01 |
| Mean SpO2 (%) | 97.428 ± 1.43 | 97.15 ± 1.31 | 96.10 ± 2.01 | 95.33 ± 2.41 | <0.01 |
| LSpO2 (%) | 93.00 ± 3.12 | 89.8 (± 3.75) | 84.54 ± 5.83 | 79.28 ± 7.11 | <0.01 |
| T90 (%) | 0 (0, 0) | 0 (0, 0.10) | 0.30 (0.05, 0.80) | 1.4 (0.35, 3.4) | <0.01 |
| TNF-α (pg/ml) | 6.51 (5.85, 7.63) | 6.7 (5.5, 8.4) | 6.8 (5.65, 16.35) | 8.1 (6.4, 9.2) | 0.20 |
| VEGF (pg/ml) | 20.68 (18.88, 27.87) | 23.08 (13.49, 34.26) | 20.68 (17.89, 31.06) | 30.263 (26.27, 43.44) | <0.01 |
| ET-1 (pg/ml) | 0.33 (0.20, 0.46) | 0.43 (0.22, 0.63) | 0.46 (0.31, 1.3) | 0.34 (0.26, 0.60) | 0.14 |
| VCAM (ng/ml) | 543.42 (472.05, 622.52) | 507.30 (437.69, 587.33) | 522.15 (450.93, 649.52) | 533.30 (486.65, 600.91) | 0.72 |
| AIx75 (%) | −15 (−18.25, −1.75) | −11 (−22, 2) | −1 (−8.5, 20) | −1 (−8, 17.5) | <0.01 |
| RHI | 1.78 ± 0.46 | 1.77 ± 0.51 | 1.98 ± 0.58 | 1.85 ± 0.44 | 0.64 |
Data presented as mean ± SD or the median with interquartile range. AI, arousal index; AHI, apnea hypopnea index; AIx75, augmentation Index@75 beats/minute; BMI, body mass index; ET-1, endothelin-1; GLU, glucose; HbA1C, hemoglobin A1C; LSpO2, lowest pulse arterial oxygen saturation; RHI, reactive hyperaemia index; SpO2, oxygen saturation; T90, percentage of sleep time with oxygen saturation <90%; TNF-α, tumor necrosis factor alpha; VCAM, vascular cell adhesion molecule; VEGF, vascular endothelial growth factor.