Table 2.
Mixed-effects model results.
| Mean arterial pressure | Systolic blood pressure | Diastolic blood pressure | ||||
|---|---|---|---|---|---|---|
| Base model | Controlled model | Base model | Controlled model | Base model | Controlled model | |
| Mean arterial pressure | 0.019*** | 0.018*** | 0.015*** | 0.014*** | 0.016** | 0.014* |
| (0.009, 0.028) | (0.008, 0.029) | (0.008, 0.021) | (0.007, 0.021) | (0.005, 0.027) | (0.002, 0.026) | |
| Time in study (years) | 0.035*** | 0.037*** | 0.026** | 0.029** | 0.041*** | 0.041*** |
| (0.017, 0.054) | (0.017, 0.057) | (0.008, 0.044) | (0.009, 0.049) | (0.023, 0.059) | (0.020, 0.062) | |
| Cohort (OA relative to MA) | −0.402 | −0.565 | −0.536 | −0.667* | −0.322 | −0.521 |
| (−0.968, 0.164) | (−1.157, 0.026) | (−1.107, 0.035) | (−1.261, −0.072) | (−0.888, 0.244) | (−1.114, 0.072) | |
| Sex (Female relative to Male) | −0.837** | −0.775** | −0.840** | −0.788** | −0.858** | −0.800** |
| (−1.402, −0.272) | (−1.357, −0.193) | (−1.405, −0.274) | (−1.370, −0.205) | (−1.423, −0.292) | (−1.381, −0.220) | |
| APOE ɛ4 carriers (relative to non-carriers) | −0.079 | −0.085 | −0.072 | |||
| (−0.693, 0.535) | (−0.701, 0.530) | (−0.686, 0.543) | ||||
| Unmedicated hypertension only | −0.01 | 0.004 | 0.017 | |||
| (−0.283, 0.263) | (−0.266, 0.275) | (−0.254, 0.289) | ||||
| Non-hypertensive only | −0.04 | 0.012 | −0.106 | |||
| (−0.378, 0.299) | (−0.329, 0.354) | (−0.437, 0.224) | ||||
| Constant | 0.073 | −0.51 | 0.15 | −0.45 | 0.163 | −0.308 |
| (−0.451, 0.598) | (− 2.722, 1.702) | (−0.368, 0.669) | (− 2.661, 1.761) | (−0.358, 0.683) | (− 2.490, 1.874) | |
| Random effects intercept | 3.633 (3.427, 3.839) | 3.615 (3.394, 3.803) | 3.641 (3.435, 3.847) | 3.622 (3.401, 3.811) | 3.636 (3.430, 3.842) | 3.616 (3.397, 3.867) |
| Random effects residual | 1.590 (1.531, 1.650) | 1.593 (1.529, 1.647) | 1.584 (1.526, 1.643) | 1.589 (1.526, 1.644) | 1.592 (1.534, 1.652) | 1.595 (1.532, 1.649) |
| Observations | 2,070 | 2,070 | 2,085 | 2,070 | 2,085 | 2,080 |
| Log Likelihood | −4,860.409 | −4,870.309 | −4,887.345 | −4,868.801 | −4,893.34 | −4,892.469 |
| Akaike Inf. Crit. | 9,734.818 | 9,784.618 | 9,788.691 | 9,781.602 | 9,800.679 | 9,826.939 |
| Bayesian Inf. Crit. | 9,774.265 | 9,908.595 | 9,828.189 | 9,905.579 | 9,840.177 | 9,945.381 |
Note. *indicates significance at p < 0.05, **p < 0.01, ***p < 0.001. Rounded brackets include 95% confidence intervals. Controlled models include education, diabetes mellitus, BMI, smoking, depression, physical activity, alcohol intake, and APOE ɛ4 genotype (coefficients not reported).