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. 2021 Oct 5;9:749210. doi: 10.3389/fcell.2021.749210

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Copyright © 2021 Wei, Chen, Hu, He, Jiang, Long and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPP1 is related to poor prognosis and upregulated in hypoxia tumor microenvironment (TME) to promote malignant phenotype of cancer. (A) The expression of SPP1 in macrophage from tumor and normal samples. ****p ≤ 0.0001, two-sided Wilcoxon rank sum test. (B) The Kaplan–Meier overall survival curves of The Cancer Genome Atlas (TCGA) patients grouped by gene expression of SPP1. (C) The correlation between SPP1 expression and SPP1+ TAM signature score with glycolysis score and EMT score in TCGA cancer samples. (D) Violin plot shows the SPP1 expression in hypoxia-high and -low macrophages in six cancer types. (E) Relative mRNA expression of SPP1 and M1 marker genes in THP-1-derived macrophage exposed to hypoxia (1% O₂) for 24 h. (F) The expression of SPP1 in macrophage exposed to hypoxia and normoxia from GSE4630 data.