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. 2021 Oct 5;12:748798. doi: 10.3389/fphar.2021.748798

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Copyright © 2021 Kurelic, Krieg, Sonner, Bhaiyan, Ramos, Frantz, Friese and Nikolaev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ANP stimulation enhances T cell activation in CD4⁺ T cells. MACS-purified Tcon were stimulated for 6 h in presence of anti-CD3/CD28 and ANP. Surface expression of CD25 and CD69 was assessed by flow cytometry. Results are presented as an activation index calculated as the difference of (A) CD25 and (B) CD69 expression between anti-CD3/CD28 stimulated and unstimulated CD4⁺ T cells. Bar graphs show quantified values of five individual animals per group. The significance of data was confirmed by repeated-measures one-way ANOVA followed by Dunett’s multiple comparison test; **p < 0.01, ***p < 0.001.