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Leave-one-out analysis of the causal effect of social isolation on osteoarthritis. Each black point represents result of the inverse-variance weighted (IVW) method applied to estimate the causal effect of social isolation on osteoarthritis excluding each particular SNP from the analysis. Each red point depicts the IVW estimate using all SNPs. No single SNP is strongly driving the overall effect of social isolation on osteoarthritis in this leave-one-out sensitivity analysis.
