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Leave-one-out analysis of the causal effect of osteoarthritis on social isolation. Each black point represents result of the inverse-variance weighted (IVW) method applied to estimate the causal effect of osteoarthritis on social isolation excluding each particular SNP from the analysis. Each red point depicts the IVW estimate using all SNPs. No single SNP is strongly driving the overall effect of osteoarthritis on social isolation in this leave-one-out sensitivity analysis.
