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. 2021 Oct 5;8:730473. doi: 10.3389/fmolb.2021.730473

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Copyright © 2021 Cai, Yang, Chen, Gong, Yi, Liao, Huang, Xie and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression analysis of the abnormally expressed proteins identified in the depression-susceptible (Dep-Sus), anxiety-susceptible (Anx-Sus), and insusceptible (Insus) groups. (A) Venn diagrams displaying the number of abnormally expressed proteins. (B) PCA of the abnormally expressed proteins based on their fold changes in the three stressed groups relative to the control (Ctrl) group. (C) Hierarchical clustering of the abnormally abundant proteins representing log2 of their fold changes in the three stressed groups in relative to the Ctrl group. Red represents upregulation, and blue represents downregulation with darker shades indicating greater changes in expression. The eight isobaric tags used are shown.