Table 2.
Clinicopathological characteristics according to preoperative serum calcitonin levels.
| Characteristics | Calcitonin level (pg/mL) | P-value | |
|---|---|---|---|
| ≤ 309 | > 309 | ||
| Age, years (mean ± SD) | 50.2 (12.1) | 48.7 (16.2) | 0.528 |
| Sex, n (%) | |||
| female | 55 (73.3) | 55 (58.5) | 0.045 |
| male | 20 (26.7) | 39 (41.5) | |
| Tumor type, n (%) | |||
| sporadic | 65 (86.7) | 74 (78.7) | 0.179 |
| hereditary (MEN2A) | 10 (13.3) | 20 (21.3) | |
| Extent of surgery, n (%) | |||
| total thyroidectomy | 73 (97.3) | 94 (100.0) | 0.195 |
| Subtotal/near total thyroidectomy | 2 (2.7) | 0 (0.0) | |
| Initial CND, n (%) | |||
| Yes | 71 (94.7) | 91 (96.8) | 0.701 |
| No | 4 (5.3) | 3 (3.2) | |
| Tumor size, cm, n (%) | |||
| ≤2.0 | 70 (93.3) | 48 (51.1) | <0.001 |
| >2.0 and ≤4.0 | 4 (5.3) | 34 (36.2) | |
| >4 | 1 (1.3) | 12 (12.8) | |
| Extrathyroidal extension, n (%) | |||
| none/micro | 72 (96.0) | 79 (84.0) | 0.012 |
| gross | 3 (4.0) | 15 (16.0) | |
| Resection margin, n (%) | |||
| negative | 74 (98.7) | 88 (93.6) | 0.134 |
| Positive | 1 (1.3) | 6 (6.4) | |
| Central LNM, n (%) | |||
| no | 61 (81.3) | 37 (39.4) | <0.001 |
| yes | 14 (18.7) | 57 (60.6) | |
| Lateral LNM, n (%) | |||
| no | 68 (90.7) | 39 (41.5) | <0.001 |
| yes | 7 (9.3) | 55 (58.5) | |
| Follow-up, months, median (IQR) | 96 (58–123) | 80 (30.5-150.5) | 0.953 |
SD, standard deviation; MEN2A, multiple endocrine neoplasia type 2A; CND, central lymph node dissection; LNM, lymph node metastasis; IQR, interquartile range.