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. 2021 Oct 5;11:747282. doi: 10.3389/fonc.2021.747282

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Copyright © 2021 Zhao, Jiang, Fang, Fang, Liu, Zhao, You, Zhou, Su, Wang, Liu, Chen, Wan and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cytotoxicity of β-Lapachone in hepatocellular carcinoma cells is NQO1-dependent. (A–F) HCC cells (HepG2 (A), Huh7 (B), Li7 (C), PLC/PRF/5 (D), SK-HEP1 (E), SNU-182 (F), and Hep3B (G), were exposed to β-lap (0-10 µM), ± dicoumarol (DIC, 50 µM) for 2 h, and then relative survival was assessed. (H, I) NQO1-overexpressing SK-HEP1 cells (H) and stable NQO1 knockout PLC/PRF/5 cells (I) were treated as in (A), and then cell viability was assessed. All error bars are means ± SDs. ***p < 0.001 (t tests). No addition, DMSO alone; DIC, dicoumarol; β-lap, β-Lapachone. Inset, NQO1 expression in NQO1-overexpressing SK-HEP1 and NQO1 knockout PLC/PRF/5 cells was confirmed by western blotting. %T/C, the mean of %Treated/Control.