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. 2021 Oct 5;12:745561. doi: 10.3389/fphar.2021.745561

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Copyright © 2021 Li, Wang, Dong, Shi, Dai, Zhao, Li, Fang, Ren, Liu, Wei, Mou, Lin, Yang, Xiao, Ma and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GER inhibits the activation of HSCs via TGF-β/Smad signaling pathway in MCD diet-induced liver fibrosis model. (A) The content of hydroxyproline in liver tissue (n = 8). (B) The serum content of PⅢNP (n = 8−11). (C) Immunohistochemistry for α-SMA and COL1A1 in liver sections (scale bars, 100 μm). (D–E) Quantification of α-SMA and COL1A1 expression in different treatment groups (n = 6). (F) Western blot for α-SMA and Smad3 protein levels in liver tissue, and β-actin was used as the loading control (n = 4). (G) Quantitative analysis of α-SMA and β-actin expression (n = 4). All data are presented as means ± SEM. ^###p < 0.001 vs. the MCS group. ^*p < 0.05, ***p < 0.001 vs. the model group.