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. 2021 Oct 5;9:749924. doi: 10.3389/fcell.2021.749924

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Copyright © 2021 Takahashi, Kobayashi, Mizutani, Hara, Iida, Miyai, Asai and Enomoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Structure of Meflin/Islr. It is a glycosylphosphatidylinositol-anchored membrane protein with five leucine-rich repeats (LRRs) flanked by cysteine-rich N- and C-terminal domains and an immunoglobulin (Ig)-like domain. (B) Meflin/Islr is an MSC marker. Meflin is highly expressed in undifferentiated MSCs, whereas its expression is downregulated upon MSC differentiation. A lineage trace experiment showed the possibility that Meflin⁺ MSCs undergo self-renewal, although this has not yet been explicitly proven. Meflin⁺ MSCs may also be involved in the maintenance of heamatopoietic stem cells in the bone marrow.