. 2021 Oct 5;12:733566. doi: 10.3389/fimmu.2021.733566

Table 1.

Phenotype of distinct B cell subsets in mice and humans.

Species	Organ	B cell subset	Markers	Literature
Mouse	BM	B lymphocyte progenitor	Ly6D⁺ IL-7Rα⁺ CD135⁺ CD3^- CD4^- CD8^- Gr-1^- CD11b^- TER-119^- CD117^- Sca-1^-	(15, 17)
		B-1 progenitor	CD19⁺ CD93⁺ CD3^- CD4^- CD8^- Gr-1^- CD11b^- TER-119^- B220^low
		B-2 progenitor	B220⁺ CD3^- CD4^- CD8^- Gr-1^- CD11b^- TER-119^- CD19^- CD93^-
		Pre-Pro B cell	B220⁺ CD43⁺ CD93⁺ CXCR4⁺ CD135⁺ IL-7Rα⁺ CD3^- CD4^- CD8^- Gr-1^- CD11b^- TER-119^- CD19^- CD24^low CD117^- IgM^-
		Pro-B cell	B220⁺ CD19⁺ CD24⁺ CD43⁺ IL-7Rα⁺ CD3^- CD4^- CD8^- Gr-1^- CD11b^- TER-119^- CD117^- IgM^-
		Pro-B cell	B220⁺ CD19⁺ CD24⁺ IL-7Rα⁺ CD3^- CD4^- CD8^- Gr-1^- CD11b^- TER-119^- CD43^- IgM^-
		Immature B cell	B220⁺ CD19⁺ CD24⁺ CD93⁺ IgM⁺ CD23^- CD43^- IgD^-
	Peritoneal Cavity	B-1a cell	CD19^high CD43⁺ CD1d^mid CD5⁺ CD23^-	(18, 19)
	Peritoneal Cavity	B-1b cell	CD19^high CD43⁺ CD1d^mid CD23^- CD5^-	(18, 19)
	Spleen	T1 B cell	B220⁺ CD19⁺ CD24⁺ CD93⁺ IgM⁺ CD43^- IgD^low	(15, 17)
		T2 B cell	B220⁺ CD19⁺ CD24⁺ CD93⁺ IgM⁺ IgD⁺ CD43^-	(15, 17)
		MZ B cell	B220⁺ CD19^mid CD21^high CD1d⁺ IgM^high CD43^- CD23^- CD93^- IgD^low	(20, 21)
		FO B cell	B220⁺ CD19^mid CD23^high CD1d^mid IgD^high CXCR5⁺ CD43^- CD21^low IgM^low	(20, 21)
		ABC	CD19⁺ BAFFR⁺ CD11b⁺ CD11c⁺ (T-bet⁺)	(22, 23)
	Lymphoid Tissue + Peripheral Blood	GC B cell	B220⁺ CD19⁺ CD40⁺ MHCII⁺	(24)
	Lymphoid Tissue + Peripheral Blood	B_REG	CD19⁺ CD1d^high CD5⁺	(25)
Human	BM	B lymphocyte progenitor	CD10⁺ CD34⁺ Pax5⁺	(16)
		Pre-Pro B cell	CD10⁺ CD34⁺ Pax5⁺ CD38⁺ CD117^-
		Pro-B cell	CD10⁺ CD34⁺ Pax5⁺ CD38⁺ CD19⁺ CD20⁺ CD24⁺ CD93⁺ IL-3R⁺ IL-7Rα⁺ CD117^-
		Pre-B cell	CD10⁺ Pax5⁺ CD38⁺ CD19⁺ CD20⁺ CD24⁺ CD93⁺ IL-3R⁺ IL-7Rα⁺ IL-4Rα⁺ CD117^- CD34^-
		Immature B cell	CD10⁺ CD38⁺ CD19⁺ CD20⁺ CD24⁺ CD93⁺ CD21⁺ CD40⁺ IL-4Rα⁺ CD117^- CD27^- IL-7Rα^-
	Peritoneal Cavity	B-1 cell	CD20⁺ CD27⁺ CD43⁺ CD38^low	(26)
	Spleen	Transitional B cell	CD38⁺ CD19⁺ CD20⁺ CD24⁺ CD93⁺ CD21⁺ CD23⁺ CD5⁺ TACI⁺ CD10^- CD27^-	(16)
		MZ B cell	CD19⁺ CD20⁺ CD21⁺ TACI⁺ CD1c⁺ CD27⁺ FCRL3⁺	(27)
		FO B cell	CD19⁺ CD20⁺ CD21⁺ TACI⁺ CD22⁺ CD23⁺ CXCR5⁺ MHCII⁺ CD10^- CD27^- CD38^low CD24^low	(27)
		ABC	CD19⁺ BAFFR⁺ CD11b⁺ CD11c⁺ (T-bet⁺)	(28, 29)
	Lymphoid Tissue + Peripheral Blood	GC B cell	CD38⁺ CD19⁺ CD20⁺ TACI⁺ CD27⁺ MHCII⁺ CD40⁺ CD83⁺	(30)
	Lymphoid Tissue + Peripheral Blood	B_REG	CD19⁺ CD24^high CD27⁺	(31)