. 2021 Oct 5;12:733566. doi: 10.3389/fimmu.2021.733566

Table 2.

Phenotypes and functions of regulatory B cells.

Species	B_REG subset	Markers	Function	Literature
Mouse	B10 cells	CD19⁺ CD5⁺ CD1d⁺	Induce T_REGS and inhibit T_H1 and T_H17 differentiation	(25)
	TIM-1⁺ B cells	CD19⁺ TIM-1⁺	Promote T_H2 and T_REG differentiation	(80)
	PD-L1⁺ B cells	CD19⁺ PD-L1⁺	Promote T_REG differentiation	(81)
	CD73⁺ B cells	B220⁺ CD39⁺ CD73⁺	Inhibit effector T cells	(82)
	B-1a FasL⁺ cells	CD19⁺ CD5⁺ FasL⁺	Mediate CD4⁺ T cell apoptosis	(83)
Human	B10 cells	CD19⁺ CD24^high CD27⁺	Induce T_REGS and suppress T_H1 and T_H17 differentiation	(31)
	PD-L1⁺ B cells	CD19⁺ PD-L1⁺	Suppress pro-inflammatory cytokine production and inhibit CD8⁺ T cell activation	(81)
	Br1 cells	CD25^high CD71^high CD73^low	Inhibit CD4⁺ T cell proliferation	(84)