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. 2021 Oct 5;15:741214. doi: 10.3389/fnins.2021.741214

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Copyright © 2021 Li, Zhao, Zhao, Huang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mGluR1 antagonist JNJ blocks the inhibitory effect of DHPG on CB response to hypoxia. (A) Effect of JNJ (20 μM) on the CSNA under hypoxia conditions. Note that DHPG reversibly enhances the CSNA under hypoxia conditions. (B) JNJ (20 μM) increases the normalized integrated CSNA during hypoxia. n = 7. (C,D) Pretreatment with JNJ prevents the inhibitory effect of DHPG on CB response to hypoxia. The data were presented as mean ± SEM. n = 4. ^∗p < 0.05 and ^∗∗∗p < 0.05 indicate significant difference (one-way ANOVA with repeated measures). CSNA, carotid sinus nerve activity; JNJ, JNJ16259685, mGluR1 antagonist.