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. 2021 Oct 5;15:741214. doi: 10.3389/fnins.2021.741214

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Copyright © 2021 Li, Zhao, Zhao, Huang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GABA_B receptor antagonist CGP52432 blocks inhibitory effect of DHPG on CB response to hypoxia. (A) Representative traces of changes in raw CSNA and integrated CSNA recordings. Note that pretreatment with CGP52432 prevents the inhibitory effect of DHPG on CSNA under hypoxia conditions. (B) Statistical analysis of normalized integrated CSNA after difference treatment. The data were presented as mean ± SEM. n = 5, ^∗p < 0.05 indicates significant difference (one-way ANOVA with repeated measures). CSNA, carotid sinus nerve activity; CGP52432, GABA_B receptor antagonist; DHPG, group I mGluRs agonist.