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. 2021 Mar 17;53(4):1174–1183. doi: 10.4143/crt.2021.031

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Copyright © 2021 by the Korean Cancer Association

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Overall survival (OS) of clear cell renal cell carcinoma patients according to ferroportin (FPN), F-Box, and leucine rich repeat protein 5 (FBXL5) and signal transducer and activator of transcription 3 (STAT3) expression. (A) In 143 clear cell renal cell carcinoma, low expression of FPN was significantly associated with shorter OS (p=0.003). (B) Similar to FPN, low FBXL5 expression was significantly associated with shorter OS (p=0.004). (C) Cases with low expression of both FPN and FBXL5 showed significantly shorter OS than other cases (p < 0.001). (D) High STAT3 expression showed significantly shorter OS (p=0.007). In patients with recurrence or metastasis, those with low FPN (E) and FBXL5 (F) expression showed significantly shorter OS (p=0.016 and p=0.015, respectively). (G) High STAT3 expression did not show significant differences in patients with recurrence or metastasis (p=0.525). (H) When analyzing 191 pT3 and pT4 patients of The Cancer Genome Atlas cohort, low mRNA expression level of FPN was significantly associated with shorter OS (p < 0.001). (I) Similar to FPN, the low mRNA expression level of FBXL5 was significantly associated with shorter OS (p=0.014).