Table 2.
Univariate and multivariate analysis of 143 clear cell renal cell carcinoma cases on overall survival
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age (yr) | ||||
|
| ||||
| ≤ 60 | 1 | 0.546 | - | - |
|
| ||||
| > 60 | 0.851 (0.504–1.437) | - | ||
|
| ||||
| Sex | ||||
|
| ||||
| Female | 1 | 0.746 | - | - |
|
| ||||
| Male | 0.909 (0.509–1.622) | - | ||
|
| ||||
| Tumor size (cm) | ||||
|
| ||||
| ≤ 9 | 1 | 0.002 | 1 | 0.899 |
|
| ||||
| > 9 | 2.351 (1.381–4.004) | 1.040 (0.570–1.896) | ||
|
| ||||
| Nuclear grade | ||||
|
| ||||
| 2 | 1 | 0.184 | - | - |
|
| ||||
| 3 and 4 | 1.661 (0.786–3.513) | - | ||
|
| ||||
| Perirenal fat invasion | ||||
|
| ||||
| Absent | 1 | 0.003 | 1 | 0.067 |
|
| ||||
| Present | 2.385 (1.338–4.251) | 1.807 (0.959–3.408) | ||
|
| ||||
| Sinus fat invasion | ||||
|
| ||||
| Absent | 1 | 0.160 | - | - |
|
| ||||
| Present | 0.689 (0.409–1.159) | - | ||
|
| ||||
| Vascular invasion | ||||
|
| ||||
| Absent | 1 | 0.349 | - | - |
|
| ||||
| Present | 1.284 (0.761–2.167) | - | ||
|
| ||||
| Necrosis | ||||
|
| ||||
| Absent | 1 | 0.246 | - | - |
|
| ||||
| Present | 1.504 (0.754–3.000) | - | ||
|
| ||||
| Sarcomatoid/Rhabdoid differentiation | ||||
|
| ||||
| Absent | 1 | < 0.001 | 1 | 0.057 |
|
| ||||
| Present | 3.474 (1.784–6.762) | 1.986 (0.979–4.031) | ||
|
| ||||
| FPN expression | ||||
|
| ||||
| High | 1 | 0.004 | 1 | 0.101 |
|
| ||||
| Low | 2.192 (1.280–3.751) | 1.616 (0.910–2.868) | ||
|
| ||||
| FBXL5 expression | ||||
|
| ||||
| High | 1 | 0.005 | 1 | 0.034 |
|
| ||||
| Low | 2.323 (1.287–4.194) | 2.001 (1.053–3.801) | ||
|
| ||||
| STAT3 expression | ||||
|
| ||||
| Low | 1 | 0.009 | 1 | 0.080 |
|
| ||||
| High | 2.207 (1.217–4.002) | 1.775 (0.934–3.375) | ||
|
| ||||
| Recurrence/Metastasis | ||||
|
| ||||
| Absent | 1 | < 0.001 | 1 | < 0.001 |
|
| ||||
| Present | 9.541 (3.786–24.043) | 7.001 (2.667–18.377) | ||
CI, confidence interval; FBXL5, F-Box and leucine rich repeat protein 5; FPN, ferroportin; HR, hazard ratio; STAT3, signal transducer and activator of transcription 3.