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. 2021 Mar 9;53(4):1042–1056. doi: 10.4143/crt.2020.1208

Fig. 8.

Fig. 8

Exogenous TGFB1 increased KCNQ1OT1 expression and activated epithelial-to-mesenchymal transition pathway in small cell lung cancer cells. Exogenous TGFB1 stimulated H69 cell lines, and the mRNA level of KCNQ1OT1, SMAD2, SMAD3, TWIST1, ZEB-2, VIM, and CDH1 were detected at 12 hours (A), 36 hours (B), and 60 hours (C), respectively. Exogenous TGFB1 stimulated H446 cell lines, and the mRNA level of KCNQ1OT1, SMAD2, SMAD3, TWIST1, ZEB-2, VIM, and CDH1 were detected at 12 hours (D), 36 hours (E), and 60 hours (F), respectively. *p < 0.05, **p < 0.01.