Table 2.

Current clinical trials utilizing DNA viruses against gliomas.

Virus type	Strain	Targeted malignancy	Routes	Latest phase	Combination therapy	Trial No.	Status
Adenovirus	SCH-58500	Brain tumor	IT	I	Conventional surgery	NCT00004080	Completed
	DNX-2440	Glioblastoma	IT	I		NCT03714334	Recruiting
	CRad-S-pk7	Brain tumor	IC	I	Neural stem cells loaded with an oncolytic adenovirus	NCT03072134	Active, not recruiting
	DNX-2401	Glioblastoma/Recurrent Tumor	IT	I	Temozolomide	NCT01956734	Completed
		Glioblastoma or Gliosarcoma	IT	I	IFN-γ	NCT02197169	Completed
		Recurring Glioblastoma	IT	I		NCT00805376	Completed
		Recurring Glioblastoma	IT(CED)	I/II		NCT01582516	Completed
		Brain tumor	IT	II	Pembrolizumab	NCT02798406	Active, not recruiting
		Recurrent Glioblastoma	IA	I		NCT03896568	Recruiting
HSV	C134	Brain tumor	IT	I		NCT03657576	Recruiting
	M032	Brain tumor	IT	I		NCT02062827	Recruiting
	rQNestin 34.5	Brain tumor	IT	I		NCT03152318	Recruiting
	G207	Brain tumor	IT	I	Radiation	NCT02457845	Active, not recruiting
		Brain tumor	IT	I/II		NCT00028158	Completed
		Pediatric brain tumor	IT	I	Radiation	NCT03911388	Recruiting
		Pediatric brain tumor	IT	II	Radiation	NCT04482933	Not yet recruiting
	HSV-1716	Pediatric brain tumor	IT	I	dexamethasone	NCT02031965	Terminated
	G47Δ	Residual or recurrent glioblastoma	IT	II		UMIN000015995	Completed
Vaccinia virus	TG6002	Glioblastoma	IV	I/II	5-flucytosine	NCT03294486	Recruiting
Parvovirus	H-1PV	Glioblastoma	IV, IT, IC	I/II		NCT01301430	Completed

IT, Intratumoral; IC, Intracavitary; IV, Intravenous; IA, Intra-arterial; CED, Convection-enhanced delivery. (The data is based on “clinicaltrials.gov”).