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. 2021 Oct 14;14:5273–5290. doi: 10.2147/JIR.S334996

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© 2021 Deng et al.

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The effect of FGF2 on EMT in renal tubular epithelial cells. The effect of Albuminuria, AGEs and FGF2 on PI3K/AKT pathway mediated expression of HPSE. HPSE can hydrolyze HSPG to generate HS fragments and inhibit the overexpression of multiligand proteoglycan-1, essential for FGF2 activation of. In addition, HPSE regulate the expression and activity of TGF-β.