Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 14;14:5273–5290. doi: 10.2147/JIR.S334996

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Deng et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

The therapeutic effect of FGF21 on DN. Endoplasmic reticulum stress activates ATF4, which induce FGF21 expression. FGF21 protects kidney damage by activating multiple signaling pathways. PI3K/AKT pathway is shown to the left, STAT5 pathway in the middle and AMPK/SIRT1 on the right.