Table 1.
FGFs and Its Specific FGF Receptors
| FGF Subfamily | FGF | Cofactor | FGF Receptor Activity | |
|---|---|---|---|---|
| Paracrine Subfamily | FGF1 subfamily | FGF1 | HS | All FGFRs |
| FGF2 | FGFR1c,3c>2c,1b,4 | |||
| FGF4 subfamily | FGF4 | FGFR1c,2c>3c,4 | ||
| FGF5 | FGFR1c,2c>3c,4 | |||
| FGF6 | FGFR1c,2c>3c,4 | |||
| FGF7 subfamily | FGF3 | FGFR2b>1b | ||
| FGF7 | FGFR2b>1b | |||
| FGF10 | FGFR2b>1b | |||
| FGF22 | FGFR2b>1b | |||
| FGF8 subfamily | FGF8 | FGFR3c>4>2c>1c≫3b | ||
| FGF17 | FGFR3c>4>2c>1c≫3b | |||
| FGF18 | FGFR3c>4>2c>1c≫3b | |||
| FGF9 subfamily | FGF9 | FGFR3c>2c>1c,3b≫4 | ||
| FGF16 | FGFR3c>2c>1c,3b≫4 | |||
| FGF20 | FGFR3c>2c>1c,3b≫4 | |||
| Endocrine Subfamily | FGF19 subfamily | FGF19 | β-Klotho | FGFR1c,2c,3c,4 |
| FGF21 | FGFR1c,3c | |||
| FGF23 | α-Klotho | FGFR1c,2c,3c,4 | ||
| Non-signal FGFs Subfamily | FGF11 subfamily | FGF11 | Is not combined with FGFRs | |
| FGF12 | ||||
| FGF13 | ||||
| FGF14 | ||||