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Precore/core protein translation is initiated from (A) different start codons of the precore/core mRNA and (B) the translation of precore protein, including HBeAg and p22cr, is abolished by emergence of precore stop codon mutation (G1896A). HBV, hepatitis B virus; HBcAg, hepatitis B core antigen; HBeAg, hepatitis B e antigen; p22cr, 22-kDa precore protein; HBcrAg, hepatitis B core-related antigen.
