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. 2021 Oct 5;9:685310. doi: 10.3389/fped.2021.685310

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Copyright © 2021 García-Ortiz, Torre-Aguilar, Morales-Ruiz, Gómez-Fernández, Flores-Rojas, Gil-Campos, Martin-Borreguero, Ariza, Roldán-Arjona and Perez-Navero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scatter plot showing comparisons of methylation status of LINE-1 in children with autism spectrum disorders (ASD) compared to controls. (A,B) Methylation levels and differentially methylated sites (CpG1–CpG5) in the LINE-1 sequence in ASD group and healthy control group. (C,D) Methylation levels and differentially methylated sites in the LINE-1 sequence in ASD group subdivided as follows: ANMR (non-mental regression group), AMR (mental regression group), and a healthy control group. The dark bars represent the mean values of each group. Asterisks indicate statistically significant differences (*P ≤ 0.05) compared to control group.