TABLE 2.

Overall quality of evidence for outcomes^a (modified GRADE; Schunemann et al., 2013).

GRADE, Grading of Recommendations, Assessment, Development and Evaluation; Sx, symptomatic; Asx, asymptomatic; DSO, days from symptom onset.

^aEach independent variable (e.g., Viral Load Stratification), was rated according to seven quality domains, with an overall quality rating in the last column. The overall quality rating was established based on the overall number of green (indicating high quality), yellow (indicating moderate quality), and red (indicating low quality) domains; blue shading indicates that the quality rating for that domain was unclear. For example, low Publication Bias and high Consistency are both rated as high quality, whereas a low Magnitude of Effect resulted in a low quality rating. Please see the Methods and Materials section for further description of the overall quality ranking.

^bCounfounder effect characterizes the degree to which all plausible confounders would tend to increase confidence in the estimated effect.