Table 2.

In vitro study: inhibition by the soybean trypsin inhibitor of teriparatide's degradation by trypsin and chymotrypsin.

Experiment	Molar ratio (mol/mol) protease: hPTH(1–34): SBTI	Percent of remaining intact hPTH(1–34)
		2 min	5 min	10 min	15 min	30 min	60 min
hPTH(1–34)		100 ± 0	100 ± 0	100 ± 0	100 ± 0	100 ± 0	100 ± 0
hPTH(1–34): trypsin	11.4: 1.0	0	0	0	0	0	0
hPTH(1–34): chymotrypsin	6.9: 1.0	0	0	0	0	0	0
hPTH(1–34): trypsin: SBTI	11.4: 1.0: 149.4	94 ± 2	94 ± 2	94 ± 2	92 ± 1	86 ± 0	77 ± 1
hPTH(1–34): chymotrypsin: SBTI	6.9: 1.0: 90.2	78 ± 1	74 ± 0	67 ± 0	59 ± 0	39 ± 0	13 ± 1

Mean (±SD); n = 2. hPTH(1–34) – teriparatide (as acetate), SBTI – soybean trypsin inhibitor.