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. 2021 Sep 29;24(10):103193. doi: 10.1016/j.isci.2021.103193

Figure 1.

Figure 1

Development and characterization of an experimental chronic kidney disease (CKD) model in mice

(A) The experimental design for the mouse CKD model.

(B) Glomerular filtration rate (GFR) in kidney of the CKD models versus shams in mice

(C) Blood urea nitrogen (BUN) in kidney of the CKD models versus shams in mice.

(D) Urine protein to creatinine ratio (uPCR) in kidney of the CKD models versus shams in mice.

(E and F) Morphology studies in kidney of the CKD models versus shams in mice.

(G) Western blot showing collagen 1 and α-SMA protein expressions in the kidney of CKD model and vehicle at the timeline indicated in the figure.

(H and I) Representative images of Picrosirius Red stain for fibrillar collagen 45 days after nephrectomy (20x magnification and scale bar, 50 μm) and quantification of interstitial fibrosis as compared with sham control, bilateral ischemia, and nephrectomy controls. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; n = 6/group unless otherwise stated. Data are represented as mean ± SEM.