REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse monoclonal anti-SMOC2	Santa Cruz Biotechnology Inc.	Cat# sc-67396; RRID: AB_2605425
Mouse monoclonal anti-α-SMA	Sigma-Aldrich	Cat# A2547; RRID: AB_476701
Rabbit polyclonal anti-Collagen 1	Abcam	Cat# ab600408; RRID: AB_10556808
Rabbit polyclonal anti-Fibronectin	Abcam	Cat# ab23750; RRID: AB_447655
Rat monoclonal anti-F4/80	Abcam	Cat# ab6640; RRID: AB_1140040
Rabbit polyclonal anti-PDGFRβ	Abcam	Cat# ab32570; RRID: AB_777165
Rabbit polyclonal anti-p-mTOR	Cell Signaling	Cat# 2971S; RRID: AB_330970
Rabbit polyclonal anti-p-Smad2/3	Cell Signaling	Cat# 13820S; RRID: AB_2631089
Rabbit polyclonal anti-p-p42/44	Cell Signaling	Cat# 4377S; RRID: AB_331775
Rabbit polyclonal anti-p-p38	Cell Signaling	Cat# 9211S; RRID: AB_331641
Rabbit polyclonal anti-p-JNK	Cell Signaling	Cat# 9251S; RRID: AB_331659
Rabbit polyclonal anti-p-Akt	Cell Signaling	Cat# 9271S; RRID: AB_329825
Rabbit polyclonal anti-BCN1 (E-8)	Santa Cruz Biotechnology Inc.	Cat# sc-48341; RRID: AB_626745
Chemicals, peptides, and recombinant proteins
ATN-161 (Ac-PHSCN-NH2)	Selleckchem	Cat# S8454
Chloroquine diphosphate salt	Sigma	Cat# C 6628-50G
GW788388	Selleckchem	Cat# S2750
LY2109761	Selleckchem	Cat# S2704
LY294002	GIBCO	Cat# PHZ1144
3-MA	Millipore Sigma	Cat# 189490-100MG
MHY1485	Millipore Sigma	Cat# 5005540001
SB203580	Selleckchem	Cat# S1076
SB273005	Selleckchem	Cat# S7540
SB431542	Selleckchem	Cat# S1067
SP600125	Selleckchem	Cat# S1460
U0126	EMD Millipore	Cat# 19-147
Mouse SMOC2 recombinant protein	R&D	Cat# 6075-SM-050
Critical commercial assays
GFR measurement: Transdermal Mini GFR Monitor	MediBeacon	Model: Q-P10A
BUN measurement: Urea Liquid Stable Reagent	Infinity/ ThermoScientic	Cat# TR12421
siRNA in vitro transfection: lipofectamine® RNAiMAX	Thermo Fisher Scientific	Cat# 13778075
Cell differentiation assay: Phalloidin-iFluor 488	Abcam	Cat# ab176753
Experimental models: cell lines
NIH-3T3 fibroblast	ATCC	CRL-1568
Experimental models: organisms/strains
Mouse: B6-Tyrc-2J/J	The Jackson Laboratory	Stock No. 000058
Mouse: B6N.Cg-Tg(Sox2-cre)1Amc/J	The Jackson Laboratory	Stock No. 014094
Mouse: C57Bl/6	The Jackson Laboratory	Stock No. 000664
Oligonucleotides
Accell SMOC2 siRNA	Horizon a PerkinElmer Company	Cat# A-049770-16-0050
Software and algorithms
Photoshop	Adobe	N/A
BioRender	App.biorender.com	BioRender Harvard
imageJ	http://imagej.net/ZContributors	Version: 2.1.0/1.53c
Prism	www.graphpad.com	Version: 9.1.0 (216)