Table 1.
Demographic and laboratory characteristics of children with MIS-C
| Parameter | n = 31 |
|---|---|
| Gender, male (%) | 19 (61.29) |
| Age in months, median(IQR), range | 96 (60, 131), 3–181 |
| Duration of illness in days, mean (SD) | 6.9 (5.7) |
| Duration of hospital stay in days, median(IQR) | 9 (6.5, 18.5) |
| Rash, n (%) | 16 (57.14) |
| Gastrointestinal symptoms, n (%) | 22 (70.96) |
| Respiratory symptoms, n (%) | 21 (67.74) |
| Hypotension, n (%) | 18 (58.06) |
| Non-purulent conjunctivitis, n (%) | 8 (25.80) |
| Mechanical ventilation, n (%) | 7 (22.5) |
| Laboratory characteristics | |
| Either RTPCR/ CBNAAT, n (%) | 10 (32.26) |
| Only antibody, n (%) | 16 (51.61) |
| Both RTPCR/ CBNAAT and antibody positive | 5 (16.13) |
| Hb (g/dL), median (IQR) | 9.31 (8.1, 10.9) |
| Total leucocyte count (/mm3), median (IQR) | 12,920 (8760, 22,400) |
| Neutrophils %, median (IQR) | 68 (46.3, 84.8), |
| Lymphocytes %, median (IQR) | 23 (9.3, 35) |
| Platelet count(× 105/mm3), median (IQR) | 3.48 (1.8, 2.6) |
| ESR (mm/h), median (IQR) | 47 (36, 90) |
| CRP(mg/dl), median (IQR) | 12.8 (3.0, 25.9) |
| Serum procalcitonin (ng/ml), median (IQR) | 8.39 (1.49, 31.89) |
| Serum ferritin(ng/ml), median (IQR) | 411.05 (195.47–1031.93) |
| D-dimer (ng/ml), median (IQR) | 3100 (500, 5250) |
| Serum fibrinogen (mg/dL), median (IQR) | 411.45 (311.16, 466.63) |
| Serum triglycerides (mg/dL), median (IQR) | 218 (125, 406) |
| SGOT (U/L), median (IQR) | 41 (26, 59) |
| SGPT (U/L), median (IQR) | 28 (15, 51) |
| Blood urea (mg/dL), median (IQR) | 38 (19, 68) |
| Serum creatinine (mg/dL), median (IQR) | 0.5 (0.3, 1.06) |
| NT-pro BNP (pg/mL), median (IQR) (normal < 125 pg/mL) |
296.52 (24.66, 4631.31) (n = 15) |
| Cytokine profile | |
| IL-6 (pg/mL),median (IQR) (0.02–10 pg/mL) |
59.52 (12.9, 194) (n = 23) |
| IL-18 (pg/mL), median (IQR) (9–812 pg/mL) |
7.59 (0.87, 94.89) (n = 12) |
| IL-2 (pg/mL), median (IQR) (0.03–90 pg/mL) |
8.92 (4.21, 53.38) (n = 12) |
| INF-γ(pg/mL), median (IQR) (0.6–124 pg/mL) |
7 (7, 29.93) (n = 12) |
| TNF-α (pg/mL),median (IQR) (0.10–98 pg/mL) |
2.5 (2.5, 36.25) (n = 12) |