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. 2021 Oct 6;46(6):250. doi: 10.3892/or.2021.8201

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — Effects of MBD2 and EZH2 on expression and promoter methylation of SFRP genes in CRC cells. (A and B) Effects of the knockdown of MBD2 and EZH2 on SFRP mRNA in SW480 (A) and HCT116 (B) cells as detected using qPCR. (C) Effects of the knockdown of MBD2 and EZH2 on the protein expression of SFRP proteins in SW480 and HCT116 as detected using western blot analysis. (D) Effects of MBD2 and EZH2 on promoter methylation of SFRP genes in SW480 and HCT116 cells. *P<0.05, **P<0.01, ***P<0.001 vs. si-NC. CRC, colorectal cancer; MBD2, methyl-CpG binding domain protein 2; EZH2, enhancer of zeste homolog 2; SFRP, secreted frizzled related protein.