Table 1. Characteristics of the Systematic Monitoring of EEG in Asphyxiated Newborns During Rewarming After Hypothermia Therapy (SMART) Cohort.
| Characteristic | No. (%) | P valuea | ||
|---|---|---|---|---|
| Group A: 72 h of hypothermia (n = 66) | Group B: 120 h of hypothermia (n = 54) | Total (N = 120) | ||
| Maternal | ||||
| Raceb | .39 | |||
| Black | 15 (23) | 12 (23) | 27 (23) | |
| White | 47 (72) | 34 (65) | 81 (69) | |
| Otherc | 3 (5) | 6 (12) | 9 (7) | |
| Age, mean (SD), y | 28.6 (6.31) | 28.2 (7.43) | 28.4 (6.81) | .58 |
| Pregnancy complications | ||||
| Chronic hypertension | 13 (20) | 12 (23) | 25 (21) | .70 |
| Antepartum hemorrhage | 9 (14) | 4 (8) | 13 (11) | .38 |
| Intrapartum complications | ||||
| Fetal decelerations | 52 (79) | 43 (83) | 95 (81) | .60 |
| Cord problem | 11 (17) | 14 (26) | 25 (21) | .21 |
| Uterine rupture | 4 (6) | 2 (4) | 6 (5) | .69 |
| Maternal pyrexia (≥37.6 °C) | 5 (8) | 8 (15) | 13 (11) | .20 |
| Shoulder dystocia | 5 (8) | 6 (11) | 11 (9) | .54 |
| Maternal hemorrhage | 11 (17) | 6 (11) | 17 (14) | .39 |
| Emergency cesarean | 45 (68) | 30 (56) | 75 (63) | .15 |
| Neonatal | ||||
| Gestational age, mean (SD), wk | 38.5 (1.51) | 38.9 (1.22) | 38.7 (1.39) | .23 |
| Outborn | 44 (67) | 34 (63) | 78 (65) | .67 |
| Female | 30 (45) | 20 (37) | 50 (42) | .35 |
| Male | 36 (55) | 34 (63) | 70 (58) | .35 |
| Apgar score ≤5 | ||||
| 5 min | 58 (89) | 43 (81) | 101 (86) | .22 |
| 10 min | 38 (67) | 33 (70) | 71 (68) | .70 |
| Intubation in delivery room | 49 (74) | 39 (74) | 88 (74) | .94 |
| Resuscitation >10 min | 54 (82) | 47 (89) | 101 (85) | .30 |
| Time to respirations >10 min | 24 (39) | 19 (38) | 43 (39) | .89 |
| Cord blood, mean (SD) | ||||
| pH | 6.92 (0.21) | 6.97 (0.17) | 6.95 (0.20) | .26 |
| Base deficit | 17.9 (8.2) | 15.1 (5.6) | 16.4 (7.1) | .23 |
| Anticonvulsant | 34 (55) | 24 (46) | 58 (51) | .36 |
| Hypothermia (33.5 vs 32.0 °C) | 39 (59) | 28 (52) | 67 (56) | .46 |
| Encephalopathy | .62 | |||
| Moderate | 54 (82) | 46 (85) | 100 (83) | |
| Severe | 12 (18) | 8 (15) | 20 (17) | |
a
P values are from χ2 test or Kruskal-Wallis test. Fisher exact test was used when data were sparse.
b
Data on race were retrieved from the parent study to control for any differences.
c
Other included individuals reporting as follows: American Indian or Alaska Native, Asian, and multiple race. These were consolidated to deidentify data due to small numbers.