Table 3. Characteristics of Infants Who Had Seizures During Rewarming.
| Characteristic | No. (%) | P valuea | |
|---|---|---|---|
| Seizures at rewarming (n = 28) | No seizures with rewarming (n = 87) | ||
| Gestational age, mean (SD), wk | 38.6 (1.57) | 38.8 (1.34) | .61 |
| Outborn | 24 (86) | 50 (57) | .007 |
| Female | 14 (50) | 37 (39) | .31 |
| Male | 14 (50) | 53 (61) | .31 |
| Apgar score ≤5 | |||
| 5 min | 25 (93) | 72 (84) | .35 |
| 10 min | 18 (75) | 50 (67) | .44 |
| Intubation in delivery room | 23 (85) | 61 (70) | .14 |
| Resuscitation >10 min | 24 (89) | 73 (87) | .76 |
| Cord blood, mean (SD) | |||
| pH | 6.97 (0.22) | 6.93 (0.19) | .50 |
| Base deficit | 14.94 (5.67) | 16.81 (7.59) | .46 |
| Anticonvulsant administration (any seizures before 72 h) | 15 (58) | 41 (49) | .46 |
| Clinical encephalopathy | .12 | ||
| Moderate | 21 (75) | 76 (87) | |
| Severe | 7 (25) | 11 (13) | |
| Abnormal brain MRI, No./No. (%)b | 19/26 (73) | 57/82 (70) | .73 |
| White matter injury | 4/19 (21) | 29/57 (51) | |
| Basal ganglia, thalamus injury | 8/19 (42) | 10/57 (18) | |
| Cerebellar involvement | 2/19 (11) | 2/57 (4) | |
| Cerebral involvement | 4/19 (21) | 7/57 (12) | |
| Amplitude EEG | <.001b | ||
| Continuous pattern | 2 (7) | 56 (64) | |
| Discontinuous pattern | 9 (32) | 13 (15) | |
| Burst suppression | 2 (7) | 7 (8) | |
| Low voltage | 12 (43) | 10 (11) | |
| Flat tracing | 3 (11) | 1 (1) | |
| Composite, death or disability at age 18-22 mo | 13 (46) | 20 (25) | .001a |
| Relative risk (95% CI) | 1.72 (1.25-2.37) | NA | |
Abbreviations: EEG, electroencephalography; MRI, magnetic resonance imaging.
a
P values are from χ2 test or Kruskal-Wallis test; Fisher exact test was used when data were sparse.
b
108 infants completed a brain MRI after the end of rewarming.