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. 2021 Oct 18;7(3):e001838. doi: 10.1136/rmdopen-2021-001838

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Proportion of patients achieving MDA over 56 weeks (NRI). Nominal p values are for upadacitinib versus adalimumab. ADA, adalimumab; DMARD, disease-modifying antirheumatic drug; EOW, every other week; MDA, minimal disease activity; NRI, non-responder imputation; PBO, placebo; QD, once daily; UPA, upadacitinib. Patients originally randomised to placebo switched to either upadacitinib 15 mg QD or upadacitinib 30 mg QDy (1:1) at week 24 and their data up to week 24 are under placebo exposure. NRI with additional rescue handling was used, where patients rescued at week 16 are imputed as non-responders. 95% CIs for response rate were calculated based on normal approximation to the binominal distribution. Nominal p value was constructed using Cochran-Mantel-Haenszel test adjusted for the main stratification factor of current DMARD use (yes/no).