Fig 4.

Postoperative differences in protein expression related to oxygen delivery intervention. (a) Key for bioinformatic prediction of up/downregulated proteins, activation or inhibition of protein function, or both. (b) Canonical pathway analysis for enriched signalling categories in organ-specific injury pathways identified through differential proteins expression in subjects in whom oxygen delivery (DO₂) target was achieved vs non-achievers. (c) Canonical pathway analysis for enriched signalling categories in skin-specific pathways for subjects who achieved or failed to achieve their individualised preoperative DO₂ value.