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. 2021 Oct 19;22:70. doi: 10.1186/s12865-021-00458-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Immunoreactivity after SARS-CoV-2 BNT162b2 mRNA vaccine in HD-patients. a IgG-antibody response to Covid-19 spike protein (Log10 anti-S). The cut-off for positive results was set to 100 AU/mL (Abbott Units/milliliter) and 50 AU/mL for negative results (quantitative method). Values between 50 and 100 AU/mL were considered borderline. b T-cell reactivity to Covid-19 spike protein (Log10). The cut off of the ELISPOT assay was set to 7 SFU/well (units). c IgG-antibody response to Covid-19 nucleocapsid antigen (anti-N). The cut-off for the qualitative method for anti-N was 1.4 S/CO (Signal to Cut-off Value). Values between 0.9 and 1.39 were consider borderline