Table III.
Drug | Selectivity | FDA approval | Common adverse effects >10% incidence | Administration in pregnancy | Interactions |
---|---|---|---|---|---|
Isocarboxazide | Non-selective MAOIs | 1959 | Weight gain, chills orthostatic hypotension, forgetful, headache, sexual dysfunction, lethargy, constipation, dizziness, serotonin syndrome | No data | Salmeterol, trazodone, alcohol, citalopram, zolpidem, duloxetine, amitriptyline, venlafaxine, escitalopram, phenelzine and lisdexamfetamine. |
Phenelzine | 1961 | Dizziness, confusion, chills, tremors, drowsiness, weakness, insomnia and dry mouth | No data | Citalopram, duloxetine, dextromethorphan, meperidine, fentanyl, tryptophan, lisdexamfetamine and vilazodone. | |
Selegiline | 1998 | Orthostasis, dizziness, nausea and abdominal pain | No | Duloxetine, escitalopram, meperidine, rasagiline, bupropion and amphetamine | |
Tranylcypromine | Selective MAO-A inhibitors | 1961 | Anxiety, dizziness, weakness and constipation. | No data | Duloxetine, citalopram, selegiline, phenelzine, escitalopram, paroxetine, pseudoephedrine and lisdexamfetamine. |
Brofaromine | 1995 | Tremor, sleep disorders, dry mouth and hypotension | No data | Warfarin, amantadine, amitriptyline, apomorphine, benzodiazepine, bupropion, dobutamine, duloxetine and ethanol. |
MAO, mono amino oxidase.