Table IV.

Selective serotonin reuptake inhibitors (164).

Drug	FDA approval	Common adverse effects >10% incidence	Administration in pregnancy	Contraindications/interactions
Cetalopram	1998	Sexual dysfunction, Sedation, drowsiness, blurred vision, insomnia, hypernatremia, nausea, eye pain or swelling, vivid dreaming, pounding heartbeats, decreased sex drive, anorgasmia, dry mouth, trembling, diarrhea and slurred speech.	No	Tryptophan, St John's Wort, 5-HTP (serotonin syndrome), cimetidine, lithium and Omeprazole
Escitalopram	2002	Headache, nausea, decreased libido, delayed ejaculation, weight gain, dose-dependent QT interval prolongation on the ECG.	Has been linked a very small increased to risk of problems for your unborn baby.	Substrates that increase CYP2D6 such as codeine, aripiprazole, or risperidone. Acetaminophen, citalopram, clonazepam, levothyroxine or quetiapine
Paroxetine	1992	Loss of appetite, nausea, asthenia diarrhea, blurred vision, constipation, dry mouth, somnolence, insomnia, headache, hypomania, nervousness, paraesthesia, dizziness and sexual dysfunction.	No	MAOI, pimozide, thioridazine, tryptophan, or warfarin Substrates of CYP2B6, CYP3A4, CYP1A2, CYP2C9 and CYP2C19.
Fluoxetine	1987	Headache, nausea, agitation, insomnia, appetite loss, Anxiety, asthenia, diarrhea and somnolence	Major birth defects during the first trimester.	Inhibits a number of isozymes of the cytochrome P450 Avoided with serotonergic drugs such as methamphetamine, MAOI, buspirone, TCA, MDMA, triptans and serotonin-norepinephrine reuptake inhibitors.
Fluvoxamine	1983	Nausea, headache, anorexia, insomnia, agitation, dizziness, nervousness, anxiety, somnolence, tremor and palpitations.	No	Fluvoxamine the following cytochrome P450; metabolizes agomelatine, amitriptyline, caffeine, alprazolam and aripiprazole.
Sertraline	–	Psychiatric side effects, anxiety, agitation, insomnia, sexual arousal disorder and diarrhea	No	Moderate of CYP2D6 inhibitor and CYP2B6 in vitro?