Table V.

Tricyclic antidepressants (165).

Drug	FDA approval	Common adverse effects >10% incidence	Administration in pregnancy	Contraindications/interactions
Amitriptyline	1961	Anticholinergic side effects, dizziness, headache, somnolence, orthostatic hypotension, loss of libido, agitation and insomnia	No	Hypersensitivity, history of myocardial infarction and history of arrhythmias. Monoamine oxidase inhibitors, anticholinergic, antipsychotics, cimetidine and antithyroid medications.
Butriptyline	Not	Similar to amitriptyline	No	Similar to amitriptyline
Clomipramine	1960	Dizziness, blurred vision, tremor, sexual dysfunction, nausea, dry mouth, fatigue, constipation, weight gain and increased appetite.	No	MAOI, quinidine (metabolized by CYP2D6) hypersensitivity, myocardial infarction, severe liver disease and narrow angle glaucoma
Desipramine	1964	Cardiac dysrhythmias and increased risk of breast cancer in women	Has not been well studied	Overactive thyroid gland, schizophrenia, manic-depression, alcoholism, suicidal thoughts, closed angle glaucoma. Aripiprazole, aripiprazole, amphetamine duloxetine, duloxetine, and lamotrigine.
Dosulepin	Not	Paraesthesias, drowsiness, dizziness, sweating, extrapyramidal symptoms and tremor, hypotension, confusion, disorientation, ECG alterations, dry mouth and urinary retention.	No	Epilepsy, myocardial infarction and hepatic failure. Potentiate the effects of alcohol, barbiturates, CNS depressants and tranquillizers.
Doxepin	Approved?	CNS: fatigue, dizziness, drowsiness, confusion and nightmares. Anticholinergic, allergy and may increase or decrease liver function in some patients.	No	MAOI and potentiates sympathomimetics Hypersensitivities, glaucoma, poor metabolizers and respiratory impairment
Imipramine	1950s	CNS: Dizziness, drowsiness, confusion, seizures, headache and anxiety.	–	–
		CVS: Orthostatic hypotension, hypertension, tachycardia.
		GIT: anorexia, epigastric distress, diarrhea Hematological: bone marrow depression.
Iprindole	–	Anticholinergic side effects and sedation	Inactivates cytochrome	Inactivates cytochrome P450 Should not be taken by alcoholics and those with liver disease.