Table VIII.

Serotonin-norepinephrine reuptake inhibitors (168).

Drug	FDA approval	Common adverse effects >10% incidence	Administration in pregnancy	Contraindications/interactions
Desvenlafaxine	2008	Insomnia, nausea, headache, diarrhea, constipation, dry mouth, dizziness, fatigue and hyperhidrosis	Only if the potential benefits justify the potential risks to the fetus	Sertraline, aripiprazole, amphetamine, bupropion, dextroamphetamine, alprazolam, duloxetine, Fish Oil, lamotrigine, lurasidone, lisdexamfetamine, escitalopram, lithium, pregabalin, acetaminophen, ascorbic acid, quetiapine, cyanocobalamin, cholecalciferol and cetirizine.
Duloxetine	2003	Nausea, somnolence, insomnia and dizziness	Increases the risk of congenital malformations, preterm birth, or pre-eclampsia	Hypersensitivity, CNS acting drugs with similar mechanism and thioridazine
Levomilnacipran	2013	Blood pressure increases, nausea/vomiting, sweating, constipation, erectile dysfunction in men and increased heart rate	Only if the potential benefits justify the potential risks to the fetus	Aripiprazole, amphetamine, dextro amphetamine, clonazepam, duloxetine, gabapenti, clonazeamn, lamotrigine, pregabalin, metformin, omeprazole, quetiapine, topiramate, tramadol and trazodone
Milnacipran	2009	Tachycardia, palpitations, dry mouth, hypertension, nausea, vomiting, headache, insomnia, dizziness, constipation, hyperhidrosis and facial flushing	Not allowed (category C)	MAOIs (serotonin syndrome), angina pectoris, myocardial infarction, epinephrine, norepinephrine, clonidine, digitalis and triptans and alcohol
Venlafaxine	2006	Headache, nausea, dry mouth, somnolence, asthenia, dizziness, failure of ejaculation and sweating.	–	Hypersensitive and with MAOI