Table 1. Solvent and Temperature Screening for Azetidinium Synthesis under Batch Conditions^a.

entry	solvent	T (°C)	t (min)	yieldb (%)
1	acetonitrile	60	60	11
2	hexane	60	60	19
3	EtOH	25	60	2
4	EtOH	60	60	30
5	EtOH	80	60	51
6	H2O	25	5	3
7	H2O	25	30	7
8	H2O	25	60	11
9	H2O	60	5	42
10	H2O	60	30	55
11	H2O	60	60	71
12	H2O	80	5	69
13	H2O	80	30	78
14	H2O	80	60	84

^aConditions: 28 mmol of epichlorohydrin, 28 mmol of diethylamine, and 5 mL of solvent.

^bDetermined by NMR, using dibromomethane as the internal standard.