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. 2021 Oct 4;15:729782. doi: 10.3389/fnins.2021.729782

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Copyright © 2021 Qin, Ai, Jordan, Guo, Li, Diao, Zhao, Liu, Xue, Wang and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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As a measure of external cerebral atrophy, SFR, the average of the maximum width of the two Sylvian fissures on the section showing them at their widest, divided by the transpineal coronal inner table diameter. Illustrative measurement of brain MRI images showing green lines in female and male patients, respectively. Measurement values are automatically generated by imaging software. Upper: A 73-year-old man with SFR 0.051: MoCA score: 20 on T1WI. Lower: A 76-year-old woman with SFR 0.068: MoCA score: 14 on T1WI. T1WI, T1 weighted image.