TABLE 4.
Effect of variables on MoCA in three linear regression models among male patients.
| Variable | β (95%CI) p-Value | ||
|
|
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| Non-adjusted | Adjust I | Adjust II | |
| Age | −0.24 (−0.46, −0.03) 0.0295 | −0.11 (−0.29, 0.06) 0.1932 | −0.10 (−0.29, 0.09) 0.2880 |
| Fazekas | |||
| 1 | −2.72 (−5.00, −0.45) 0.0203 | −2.67 (−4.91, −0.43) 0.0211 | −2.76 (−5.04, −0.49) 0.0188 |
| 2 | −9.00 (−11.29, −6.72) <0.0001 | −8.21 (−10.54, −5.88) <0.0001 | −8.49 (−10.85, −6.13) <0.0001 |
| 3 | −10.07 (−12.67, −7.46) <0.0001 | −9.19 (−11.87, −6.51) <0.0001 | −9.34 (−12.08, −6.60) <0.0001 |
| HBP | −3.76 (−6.61, −0.90) 0.0110 | −1.60 (−3.93, 0.73) 0.1792 | −1.22 (−3.60, 1.15) 0.3151 |
| Diabetes | 0.19 (−1.97, 2.35) 0.8638 | 1.48 (−0.21, 3.17) 0.0891 | 1.54 (−0.25, 3.34) 0.0943 |
| CHD | −0.51 (−2.93, 1.91) 0.6803 | −0.79 (−2.67, 1.09) 0.4131 | −0.80 (−2.89, 1.28) 0.4526 |
| Stroke | −4.98 (−7.42, −2.54) 0.0001 | −2.95 (−4.98, −0.92) 0.0051 | −2.98 (−5.10, −0.87) 0.0064 |
| SFR >0.05 | −2.72 (−4.92, −0.52) 0.0168 | −0.92 (−2.75, 0.90) 0.3218 | −1.01 (−2.84, 0.82) 0.2808 |
| Creatinine > = 111 | 0.89 (−1.84, 3.63) 0.5224 | 1.88 (−0.42, 4.17) 0.1112 | 2.48 (−0.79, 5.75) 0.1392 |
| Uric acid > = 428 | −0.81 (−3.30, 1.67) 0.5231 | −0.02 (−2.03, 1.98) 0.9820 | 0.82 (−2.14, 3.79) 0.5875 |
| α−HBDH > = 182 | 0.02 (−3.15, 3.18) 0.9914 | 0.26 (−2.23, 2.76) 0.8368 | −0.89 (−4.71, 2.93) 0.6501 |
| HSCRP > = 3 | 0.08 (−2.19, 2.35) 0.9465 | 0.72 (−1.03, 2.47) 0.4221 | 0.52 (−1.48, 2.51) 0.6131 |
| TC > = 5.2 | −1.70 (−5.57, 2.17) 0.3901 | −1.32 (−4.35, 1.72) 0.3966 | −2.40 (−6.35, 1.56) 0.2370 |
| TG > = 1.7 | 0.60 (−1.94, 3.14) 0.6443 | 0.42 (−1.57, 2.42) 0.6773 | −0.76 (−4.21, 2.69) 0.6681 |
| HDLC > = 1 | 0.85 (−1.38, 3.08) 0.4570 | −0.35 (−2.18, 1.49) 0.7124 | −0.63 (−3.07, 1.81) 0.6153 |
| LDLC > = 3.4 | −0.12 (−4.15, 3.92) 0.9544 | −0.34 (−3.50, 2.81) 0.8321 | −1.32 (−5.37, 2.73) 0.5251 |
| APOA > = 1.6 | 3.31 (0.54, 6.08) 0.0205 | 2.16 (−0.05, 4.38) 0.0579 | 1.34 (−1.26, 3.94) 0.3135 |
| APOB > = 1.25 | 2.71 (−2.64, 8.06) 0.3219 | 4.62 (0.51, 8.72) 0.0290 | 2.51 (−3.17, 8.19) 0.3889 |
Adjusted model 1 was adjusted for risk factors of CSVD (Fazekas; age; hypertension; diabetes; coronary heart disease; and stroke). Adjusted model 2 was adjusted for all covariables.
HBP, hypertension; CHD, coronary heart disease; SFR, Sylvian fissure ratio; α-HBDH, α-hydroxybutyrate dehydrogenase; HSCRP, high-sensitivity C-reactive protein; TC, total cholesterol; TG, total triglyceride; HDLC, high-density lipoprotein cholesterol; LDLC, low-density lipoprotein cholesterol; APOA, apolipoprotein A; and APOB, apolipoprotein B.