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Macrophage-mediated phagocytosis regulated by the CD47–SIRPα pathway. (A) The CD47–SIRPα interaction inhibits macrophage-mediated phagocytosis on tumor cells. (B) The interaction of CD47–SIRPα can be blocked by the anti-CD47 antibody to restore the macrophage-mediated phagocytosis against tumor cells. SIRPα, signal-regulatory protein alpha; CD47, cluster of differentiation 47.
