Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 4;12:735446. doi: 10.3389/fphar.2021.735446

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Liu, Yang, Chen, Xu, Yang, Yu, Li, Dong, Han, Cao, Qi, Su, Xu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Construction, uptake, release, and efficacy of DOX-Tf@PSiNPs. (A) P-type silicon wafers are used to prepare porous silicon (PSi) films by electrochemical etching, and PSiNPs are formed by mechanical milling. UA-functionalized PSiNPs (UnPSiNPs) conjugate Tf through a two-step EDC/NHS reaction, and further loading DOX to form DOX-Tf@PSiNPs. (B) Nanoparticles can be combined with TfR through Tf to achieve targeting ability across the BBB into GBM cells, and release DOX in a pH-dependent way.