FIGURE 2.

Preparation of targeted GO. GO is prepared from graphite through the tour method. The mixture of GO and DXT was stirred for 24 h at room temperature in darkness to prepare GO-DXT. Tf-PAH is synthesized through the formation of amide linkages between COOH groups of Tf and NH2 groups of PAH through EDC and NHS as the coupling reagents. Tf-PAH-(GO-DTX) is prepared by stirring the mixture of GO-DXT and Tf-PAH for 10 h at room temperature in darkness. Tf-PAH-(GO-DTX) could be taken up into MCF-7 cells by targeting TfR which would exert toxic effects.