Figure 3.

The browser with several tracks turned on and highlighting a substitution flagged early in UCSC’s community annotation at position 23403 (D614G) in the S spike glycoprotein gene. Due to the prompt nature of community driven annotation, this was available on our browser as soon as the annotation was published as a pre-print. It is labelled as a common missense mutation in SARS-CoV-2 with a notably high difference in resulting isoelectric point (D→G). Studies have shown this missense mutation in the spike protein is predominantly observed in Europe (26); patterns that were also observed in the variation data we host when first imported.