Skip to main content
. 2021 Oct 15;246(19):2128–2135. doi: 10.1177/15353702211032549

Figure 2.

Figure 2.

Type-A GABA receptor function-structure. (a) Type-A GABA receptor is a pentameric assembly with five transmembrane subunits that form a ligand-gated ion channel. Shown are binding sites for two GABA ligands (yellow spheres) and benzodiazepine (red sphere). (b) Type-A GABA receptors function to move chloride anions across the cell membrane in response to the binding of its ligand (agonist) GABA. Benzodiazepines are positive allosteric modulators of the receptors and so act to enhance movement of chloride anions when GABA is bound to the receptor.